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CAS NO:
920-66-1
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Basic Info
CAS Number
920-66-1
Pharmacopoeia
In-house Standards
Grade
Industrial grade
Is Manufacturer
No
Samples Provided
NO
Product Description
Electronic raw materials
AI Product Description
*The following content is generated by AI and is for reference only.
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP), identified by CAS number 920-66-1, is a highly polar fluorinated alcohol with the molecular formula C3H2F6O. This colorless liquid is renowned for its unique physicochemical properties, making it an indispensable solvent in advanced chemical synthesis and analytical applications. Its structure features a trifluoromethyl group on both sides of the hydroxyl-bearing carbon, which significantly enhances its acidity and hydrogen-bonding donor capability compared to standard alcohols like ethanol or methanol.
The primary utility of HFIP lies in its exceptional ability to dissolve challenging polymers, particularly those containing aromatic rings or strong intermolecular forces. It is widely used in the preparation of polyimides, polycarbonates, and other high-performance plastics that are otherwise insoluble in common solvents. In the pharmaceutical industry, HFIP serves as a critical medium for protein folding studies and peptide analysis due to its capacity to disrupt secondary structures and stabilize unfolded states without denaturing biological samples irreversibly. Furthermore, it acts as a powerful catalyst promoter in organic reactions, facilitating nucleophilic substitutions and accelerating reaction rates through specific solvation effects.
In mass spectrometry and chromatography, HFIP is frequently employed as a mobile phase additive or ionization agent because it suppresses non-specific interactions and improves peak resolution. Its low surface tension and high dielectric constant also make it valuable in electrochemistry and battery research. Additionally, the compound plays a vital role in the production of fluoropolymers and as a precursor for various fluorinated intermediates in agrochemical and materials science sectors. Despite its effectiveness, handling requires care due to its corrosive nature and potential toxicity upon prolonged exposure. Overall, 1,1,1,3,3,3-Hexafluoro-2-propanol remains a cornerstone reagent in modern laboratories, bridging the gap between fundamental research and industrial-scale manufacturing across diverse scientific disciplines. Its versatility ensures continued demand in fields ranging from nanotechnology to drug discovery, where precise control over molecular interactions is paramount.
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