Category:
Prophylactic Biological Products
CAS NO:
705260-08-8
Standard:
ChP,USP,BP,EP,JP,
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Basic Info
CAS Number
705260-08-8
Pharmacopoeia
ChP,USP,BP,EP,JP
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
CAS NO:705260-08-8
AI Product Description
*The following content is generated by AI and is for reference only.
Vorapaxar Sulfate is a potent oral anticoagulant agent designed to inhibit thrombin-activated protease-activated receptor 1 (PAR-1). Synthesized as the sulfate salt of vorapaxar, this pharmaceutical compound serves as a critical therapeutic intervention for patients at high risk of cardiovascular events. The molecular formula of Vorapaxar Sulfate is C29H34ClN5O6S2, reflecting its complex structure which includes a chlorophenyl group and a sulfonamide moiety essential for its binding affinity. Its unique Chemical Abstracts Service (CAS) registry number is 850272-54-7, distinguishing it from other antithrombotic agents currently available in the global market.
The primary clinical application of Vorapaxar Sulfate involves the reduction of thrombotic events in patients with a history of myocardial infarction or peripheral arterial disease. Unlike traditional antiplatelet therapies such as aspirin or clopidogrel, which target platelet aggregation through different mechanisms, Vorapaxar acts specifically by blocking the PAR-1 receptor on platelets. This blockade prevents thrombin-induced platelet activation, thereby inhibiting the propagation of thrombus formation without directly affecting bleeding time in the same manner as direct thrombin inhibitors. Consequently, it offers a distinct pharmacological profile aimed at preventing recurrent ischemic events while managing bleeding risks carefully.
Regulatory approval for Vorapaxar Sulfate was granted by major health authorities, including the U.S. Food and Drug Administration (FDA), marking a significant advancement in secondary prevention strategies for coronary artery disease. It is typically administered as an adjunct therapy alongside standard care regimens, such as aspirin and/or clopidogrel, though caution is required due to the increased risk of intracranial hemorrhage in specific patient populations. Clinical guidelines emphasize strict patient selection criteria, particularly excluding those with a prior history of stroke or transient ischemic attack. As research continues into optimizing dosing strategies and long-term safety profiles, Vorapaxar Sulfate remains a cornerstone in modern cardiology for mitigating the burden of atherosclerotic vascular disease. Its development represents a targeted approach to hemostasis, balancing efficacy against potential adverse effects in chronic management protocols.
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