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CAS NO:
60857-08-1
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Basic Info
CAS Number
60857-08-1
Pharmacopoeia
ChP,USP,BP,EP,JP,ChP
Product Keywords
Prostratin ,,Intermediates
Is Manufacturer
No
Samples Provided
NO
Packaging & Delivery
Packaging Specification
packaging :
shipping_port :
shipping_port :
Product Description
AI Product Description
*The following content is generated by AI and is for reference only.
Prostratin is a potent natural phorbol ester derivative isolated from the bark of the Hawaiian tree *Harpullia pendula*. Chemically known as 12,13-didehydro-4β,5α,9α-trihydroxyphorbol-20-acetate, its molecular formula is C₂₁H₂₈O₆ and it bears the CAS registry number 118764-03-9. This compound belongs to a class of substances that act as tumor promoters by mimicking diacylglycerol (DAG), a key second messenger in cellular signaling pathways. Structurally, Prostratin shares significant homology with other bioactive phorbol esters but possesses unique pharmacological properties that distinguish it within research applications.
The primary scientific utility of Prostratin lies in its ability to reactivate latent HIV-1 provirus from resting CD4+ T cells without inducing excessive cell toxicity or proliferation. Unlike many other latency-reversing agents that trigger global T-cell activation and potential cytokine storms, Prostratin specifically targets the protein kinase C (PKC) pathway to reverse viral latency while maintaining cell viability. This "shock and kill" strategy aims to purge the viral reservoir, a critical hurdle in achieving a functional cure for HIV/AIDS. Consequently, it has become a vital tool in antiretroviral therapy research, helping scientists evaluate combination therapies designed to eradicate persistent infection.
Beyond HIV research, Prostratin serves as an important probe for studying signal transduction mechanisms involving PKC isoforms and gene expression regulation. Its high specificity allows researchers to dissect complex intracellular cascades related to inflammation, differentiation, and apoptosis. While not currently approved as a clinical drug due to the need for further safety profiling regarding long-term exposure and off-target effects, its role in basic science remains indispensable. Ongoing studies continue to explore structural analogs to enhance potency and reduce potential side effects, aiming to translate these findings into effective therapeutic interventions for chronic viral infections and potentially other diseases characterized by cellular dormancy.
![4-[[[[6-[(Diethylamino)methyl]-2-naphthalenylmethoxy]carbonyllaminolbenzoic acid](https://eimg.pharmasources.com/image/20241206/xJCFsdgfMrHzqjtgeOixhGQHgVbKi7kAcoEqemzE.jpg)
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