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Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 132g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales143@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Merrifield Resin, chemically known as chloromethylated polystyrene-divinylbenzene copolymer, is a foundational solid support widely utilized in solid-phase organic synthesis. Its molecular formula is generally represented by the repeating unit (C8H7Cl)n, though the exact stoichiometry varies based on the degree of cross-linking and functionalization. The product does not possess a single unique CAS number due to its polymeric nature; however, it is commonly associated with CAS Registry Number 25901-39-1 for the specific chloromethylated variant or 25952-46-1 for the base resin. This material consists of a rigid, porous matrix formed from styrene and divinylbenzene, where a portion of the aromatic rings are substituted with reactive chloromethyl groups (-CH2Cl).
The primary application of Merrifield Resin lies in peptide synthesis, nucleic acid chemistry, and combinatorial library generation. Developed by R. Bruce Merrifield, who was awarded the Nobel Prize for this innovation, the resin revolutionized chemical manufacturing by allowing reactions to be performed on a solid phase. This approach simplifies purification, as excess reagents and byproducts can be easily removed through simple filtration and washing steps, eliminating the need for tedious crystallization or chromatography after every reaction cycle. The chloromethyl group serves as an anchor point, covalently attaching the first building block of a target molecule via nucleophilic substitution. Once the synthesis sequence is complete, the final compound is cleaved from the resin using specific reagents, yielding high-purity products.
Beyond peptides, Merrifield Resin is extensively used in the production of small molecule libraries for drug discovery and materials science. Its mechanical stability and chemical resistance allow it to withstand various solvents and harsh reaction conditions. The degree of cross-linking typically ranges from 1% to 4%, influencing the swelling properties and accessibility of internal sites within the polymer beads. Due to its versatility and reliability, Merrifield Resin remains an indispensable tool in modern synthetic laboratories, facilitating rapid exploration of chemical space and accelerating the development of new pharmaceuticals and advanced materials.
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