Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales141@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Knorr-2-Chlorotrityl Resin is a specialized solid-phase synthesis support widely utilized in the pharmaceutical and chemical industries for the efficient production of complex organic molecules, particularly peptides and small-molecule libraries. Chemically, this resin consists of polystyrene beads functionalized with 2-chlorotrityl chloride groups, which serve as robust linkers capable of attaching various carboxylic acid substrates under mild conditions. The molecular formula of the active linker moiety attached to the polymer backbone is often represented by the structural unit C19H13ClO, though the complete resin system includes the cross-linked polystyrene matrix, making its overall empirical representation dependent on the degree of substitution and cross-linking density. While a single universal CAS number does not exist for all variations due to different loading capacities and bead sizes, the core 2-chlorotrityl chloride functionality is frequently associated with specific catalog identifiers used by manufacturers like Merck or Sigma-Aldrich.
The primary utility of Knorr-2-Chlorotrityl Resin lies in its ability to facilitate acid-labile cleavage, allowing for the gentle release of synthesized compounds without harsh acidic conditions that might degrade sensitive functional groups. This characteristic makes it indispensable for synthesizing C-terminal carboxylic acids, including peptide fragments, where preserving stereochemistry and avoiding side reactions is critical. Researchers employ this resin in automated peptide synthesizers and manual protocols to construct sequences ranging from short oligopeptides to larger therapeutic candidates. Its high loading capacity ensures excellent yields, while the stability of the trityl linkage during standard deprotection steps minimizes premature cleavage. Furthermore, the resin supports the synthesis of diverse compound classes beyond peptides, such as nucleosides and small molecule inhibitors, expanding its versatility in drug discovery pipelines. By offering a balance between stability during synthesis and ease of cleavage, Knorr-2-Chlorotrityl Resin remains a cornerstone material in modern combinatorial chemistry and medicinal research, enabling the rapid generation of diverse chemical libraries for high-throughput screening and biological evaluation.