List of Homobifunctional PEG Derivatives:
COOH-PEG-COOH: Carboxyl PEG Carboxyl1
SCM-PEG-SCM: PEG (Succinimidyl Carboxymethyl Ester)21
NH2-PEG-NH2: Amine PEG Amine, HCl Salt2
MAL-PEG-MAL: Maleimide PEG Maleimide2
ACLT-PEG-ACLT: Acrylate PEG Acrylate2
HS-PEG-SH: Thiol PEG Thiol3
VS-PEG-VS: Vinylsulfone PEG Vinylsulfone3
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Homobifunctional PEG Derivatives</strong> are polyethylene glycol polymers functionalized with identical reactive groups at both termini, synthesized via nucleophilic substitution or ring-opening polymerization. These reagents facilitate bioconjugation and polymer crosslinking. Specific molecular formulas and CAS numbers vary by chain length (e.g., mPEG-NHS) and require precise specification.</p>
<h3>Application</h3>
<ul>
<li>Antibody-Drug Conjugates (ADCs): Linking cytotoxic payloads to targeting antibodies.</li>
<li>Protein Therapeutics: Extending circulation half-life of recombinant proteins.</li>
<li>Diagnostics: Labeling enzymes and fluorophores for immunoassays.</li>
<li>Material Science: Fabricating hydrogels and drug-eluting stents.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at -20°C to prevent hydrolysis. Avoid direct skin contact; use appropriate PPE due to potential sensitization. Clinical applications strictly adhere to GMP standards and regulatory purity thresholds.</p>