JenKem Technology 为商业制药应用和临床试验提供高纯度(97% 及更高)的 JK-0315-CA(ALC-0315 类似物)的大规模 GMP 生产。JK-0315-CA (ALC-0315 类似物) 是一种用于脂质纳米颗粒 (LNP) 的高质量试剂。
LNP 药物递送系统通常用于核酸递送。通常认为 LNP 通过非共价亲和力与细胞膜结合并被内吞作用吸收。被细胞吸收后,LNP 递送的 mRNA 被释放到细胞质中并表达靶蛋白,从内吞作用中逃脱。近年来,制药公司已采用这项技术生产 COVID-19 疫苗1。
请访问 https://jenkemusa.com/products-for-lnps-and-rna-delivery,了解我们的 PEG 和 LNP 小分子产品线。请联系我们 sales@jenkemusa.com 获取 JK-0315-CA(ALC-0315 类似物)的大规模 GMP 生产的报价。
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>JK-0315-CA is a proprietary <strong>ALC-0315 analogue</strong> designed for lipid nanoparticle (LNP) formulations. It serves as a critical ionizable cationic lipid in mRNA vaccine manufacturing, enabling efficient cellular uptake and endosomal escape. The compound features optimized pKa values for enhanced stability and transfection efficiency compared to standard analogues.</p>
<h3>Application</h3>
<ul>
<li><strong>Vaccine Development:</strong> Core component in mRNA-based therapeutic vaccines for infectious diseases.</li>
<li><strong>Gene Therapy:</strong> Delivery vector for siRNA and CRISPR-Cas9 systems in preclinical research.</li>
<li><strong>Protein Replacement:</strong> Facilitates delivery of mRNA encoding therapeutic proteins in rare genetic disorders.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly store under inert atmosphere at -20°C to prevent oxidation. Handling requires appropriate PPE due to potential sensitization risks. Clinical use is currently limited to investigational trials; regulatory approval status varies by jurisdiction.</p>