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Products

Chiral Intermediates

Minocycline HCl

Category:

Chiral Intermediates

CAS NO:

13614-98-7

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia,Middle East

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Beijing Hope Pharmaceutical Co., Ltd.

Years

Show Room

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Basic Info

CAS Number

13614-98-7

Pharmacopoeia

In-house Standards

Grade

Chemical Grade

Is Manufacturer

YES

Samples Provided

YES

Product Description

Beijing Hope Pharmaceutical Co., Ltd. is a high-tech pharmaceutical company based in China and facing the world. The main business is R&D, production and sales of APIs and APIs, import and export trade, R&D of new pharmaceutical preparations and new drug registration. We have an R&D center in Beijing, a pharmaceutical intermediate production base in Hebei and Zhejiang, and a GMP-certified API production base in Shandong.

AI Product Description

*The following content is generated by AI and is for reference only.

Minocycline Hydrochloride, commonly known as Minocycline HCl, is a semi-synthetic tetracycline antibiotic derived from oxytetracycline. With the chemical formula C23H27N3O8 and CAS Registry Number 13614-98-7, this compound serves as a potent broad-spectrum antimicrobial agent widely utilized in both human and veterinary medicine. Its molecular structure features four fused rings characteristic of the tetracycline class, modified to enhance lipophilicity and tissue penetration compared to earlier generations of antibiotics. The primary clinical application of Minocycline HCl involves the treatment of various bacterial infections, including acne vulgaris, respiratory tract infections, urinary tract infections, and skin conditions such as rosacea and folliculitis. Due to its superior ability to cross biological barriers, it is particularly effective against intracellular pathogens and is often the drug of choice for severe inflammatory acne that has not responded to other therapies. Furthermore, it exhibits anti-inflammatory properties independent of its antibacterial activity, making it valuable in managing autoimmune disorders like rheumatoid arthritis and multiple sclerosis in research settings. Mechanistically, Minocycline functions by binding reversibly to the 30S ribosomal subunit of bacteria, thereby inhibiting protein synthesis and preventing bacterial replication. It demonstrates efficacy against a wide range of Gram-positive and Gram-negative organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and certain strains of Neisseria gonorrhoeae. However, resistance can develop through efflux pumps or ribosomal protection mechanisms. Common side effects may include gastrointestinal disturbances, dizziness, vestibular toxicity, and skin pigmentation changes with long-term use. As with all antibiotics, appropriate medical supervision is essential to ensure therapeutic efficacy while minimizing the risk of adverse reactions and the emergence of resistant bacterial strains. This versatile medication remains a cornerstone in dermatological and infectious disease management globally.