Heterobifunctional PEG derivatives are useful as cross-linking agents or as spacers between two different entities. The PEG moiety in the heterobifunctional PEG derivatives provides water solubility, biocompatibility, and flexibility.
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<h3>Overview</h3>
<p>Heterobifunctional PEG Derivatives are <strong>polyethylene glycol</strong> chains functionalized with two distinct reactive groups. These compounds facilitate site-specific conjugation in <strong>bioconjugation</strong> processes via amine or sulfhydryl chemistry.</p>
<h3>Application</h3>
<ul>
<li><strong>Antibody-Drug Conjugates (ADCs)</strong>: Linking cytotoxic payloads to monoclonal antibodies.</li>
<li><strong>Protein Therapeutics</strong>: Extending serum half-life of recombinant proteins and enzymes.</li>
<li><strong>Diagnostics</strong>: Labeling biomolecules for immunoassays and imaging probes.</li>
</ul>
<h3>Precautions</h3>
<p>Store under <strong>-20°C</strong> in a desiccator to prevent hydrolysis. Handle in a fume hood due to potential sensitization risks. Strict purity validation is required for clinical formulations.</p>