Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales127@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
H-Ser(tBu)-2-Chlorotrityl Resin is a specialized solid-phase synthesis reagent widely utilized in the pharmaceutical and biotechnology industries for the efficient production of complex peptides and peptidomimetics. Chemically, this resin consists of L-serine protected at the hydroxyl side chain with a tert-butyl (tBu) group, covalently linked to a 2-chlorotrityl chloride polystyrene support. The molecular formula of the active amino acid moiety attached to the linker is C13H18ClNO4, though the full resin structure includes the polymer backbone. While specific CAS numbers vary depending on the manufacturer and substitution level, the core chemical entity is generally recognized under distinct catalog identifiers rather than a single universal CAS, as it is a heterogeneous material.
The primary utility of H-Ser(tBu)-2-Chlorotrityl Resin lies in its ability to facilitate the synthesis of C-terminal carboxylic acid peptides under mild conditions. Unlike standard Wang resins which require strong acidic cleavage that might affect sensitive protecting groups, the 2-chlorotrityl linker allows for gentle release using weak acids like dichloroacetic acid or trifluoroacetic acid mixtures in organic solvents. This feature is critical for preserving the integrity of acid-labile side-chain protecting groups and preventing racemization during the final cleavage step. The tBu protection on the serine residue ensures that the hydroxyl group remains inert during the automated peptide assembly process, preventing unwanted side reactions such as O-acylation.
This product is indispensable for researchers developing bioactive peptides, including therapeutic agents, diagnostic markers, and vaccine candidates. Its compatibility with various Fmoc-based synthesis protocols makes it a staple in modern medicinal chemistry laboratories. By providing a robust platform for attaching the first amino acid, it streamlines the workflow from initial coupling to final purification. The high loading capacity and stability of the resin ensure consistent yields and reproducibility across different synthesis batches. Consequently, H-Ser(tBu)-2-Chlorotrityl Resin serves as a fundamental building block for advancing drug discovery efforts, enabling the rapid generation of diverse peptide libraries with precise structural control.