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H-Ile-2-Chlorotrityl Resin
Price Range:
Get Quote
Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 110g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales121@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
H-Ile-2-Chlorotrityl Resin is a specialized solid-phase synthesis reagent widely utilized in the field of peptide chemistry for the efficient preparation of complex peptides and peptidomimetics. This product consists of L-isoleucine covalently attached to a 2-chlorotrityl chloride resin support, serving as a crucial building block for automated and manual peptide synthesis workflows. The molecular formula of the free amino acid component is C6H13NO2, while the full resin-bound structure incorporates the polymeric polystyrene backbone and the specific linker moiety, though an exact global molecular weight is often undefined due to the heterogeneous nature of the resin matrix. The CAS number associated with the H-Ile-2-Chlorotrityl Resin system is typically not assigned a single universal identifier because it represents a composite material rather than a discrete small molecule; however, the precursor 2-chlorotrityl chloride resin generally carries CAS 80754-94-7, and L-isoleucine has CAS 73-32-5.
The primary utility of this resin lies in its ability to facilitate the synthesis of C-terminal carboxylic acids or amides under mild acidic conditions. Unlike Fmoc-based resins that require strong trifluoroacetic acid (TFA) cleavage, the 2-chlorotrityl linker allows for the release of the peptide using very weak acids, such as dilute dichloromethane solutions containing low percentages of TFA or acetic acid. This gentle cleavage profile is particularly advantageous for synthesizing peptides containing acid-sensitive protecting groups or post-translational modifications that might otherwise degrade during standard harsh deprotection procedures. Furthermore, the steric bulk of the isoleucine side chain provides specific conformational constraints useful in designing bioactive sequences. Researchers frequently employ this reagent in combinatorial chemistry libraries and medicinal chemistry projects where high purity and yield are paramount. Its compatibility with standard Fmoc/t-Bu strategy protocols makes it a versatile tool for laboratories developing therapeutic agents, diagnostic markers, and research probes. By ensuring the stability of the growing peptide chain until the final cleavage step, H-Ile-2-Chlorotrityl Resin significantly enhances the overall efficiency and success rate of solid-phase peptide synthesis campaigns.
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