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H-His(Trt)-2-Chlorotrityl Resin
Price Range:
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 109g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales120@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
H-His(Trt)-2-Chlorotrityl Resin is a specialized solid-phase synthesis reagent widely utilized in the field of peptide chemistry and medicinal research. Its primary function serves as a robust support matrix for the automated or manual synthesis of histidine-containing peptides. The molecule features an N-terminal free amine protected by a trityl (Trt) group, ensuring that the imidazole side chain of the histidine residue remains shielded from unwanted reactions during the coupling process. This specific protection strategy is crucial for maintaining the integrity of histidine, which is prone to racemization and side reactions under standard acidic conditions.
The resin itself consists of a polystyrene-based backbone functionalized with 2-chlorotrityl chloride linkers. This linker offers a distinct advantage over traditional acid-labile linkers like Wang resins because it allows for the cleavage of the synthesized peptide under very mild acidic conditions, typically using low concentrations of trifluoroacetic acid (TFA) in dichloromethane. This gentle release mechanism is particularly beneficial for synthesizing sensitive peptides containing acid-sensitive protecting groups or complex structures that might degrade under harsher cleavage protocols.
Regarding its chemical specifications, while exact molecular weights vary based on substitution levels, the core structure relies on the chlorotrityl moiety attached to the resin bead. It does not possess a single CAS number applicable to all batches due to variations in resin loading capacities and cross-linking degrees; however, it is generally cataloged under specific supplier codes. The product is indispensable in pharmaceutical development for creating peptide libraries, studying protein-protein interactions, and developing therapeutic candidates involving histidine motifs. Its high stability during synthesis steps ensures excellent yields and purity, making it a preferred choice for researchers aiming to produce high-quality histidine-rich sequences without compromising the stereochemical configuration. Consequently, H-His(Trt)-2-Chlorotrityl Resin stands as a critical tool in modern organic synthesis, facilitating the efficient production of biologically active peptides for diagnostic and therapeutic applications.
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