Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales119@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
H-Gly-2-Chlorotrityl Resin is a specialized solid-phase synthesis reagent widely utilized in peptide chemistry and medicinal research. Its molecular formula is C18H14ClNO, corresponding to a CAS number of 135679-07-9. This resin consists of glycine (Gly) covalently attached via its carboxyl group to the hydroxyl moiety of 2-chlorotrityl chloride resin. The 2-chlorotrityl linker serves as an acid-labile support, offering distinct advantages over traditional linkers by allowing cleavage under mild acidic conditions, typically using dilute trifluoroacetic acid (TFA) in dichloromethane, without requiring strong scavengers that might modify sensitive side chains.
The primary application of H-Gly-2-Chlorotrityl Resin lies in the automated or manual synthesis of peptides, particularly for generating N-terminal protected fragments or complex peptidomimetics. By anchoring the first amino acid, glycine, to the solid support, chemists can efficiently build peptide sequences from the C-terminus to the N-terminus. Glycine is often chosen as the starting residue due to its small size and lack of a chiral center, which simplifies steric interactions during chain elongation. This resin is compatible with standard Fmoc (9-fluorenylmethoxycarbonyl) and Boc (tert-butyloxycarbonyl) protection strategies, making it versatile for various synthetic protocols.
In pharmaceutical development, this material plays a crucial role in producing drug candidates containing specific peptide motifs. Its ability to release the final product with high purity and minimal racemization makes it ideal for synthesizing bioactive peptides used in enzyme inhibition studies, antibody-drug conjugates, and diagnostic agents. Furthermore, the stability of the chlorotrityl linkage during coupling reactions ensures high yield and reduces byproduct formation. Researchers value this resin for its ease of handling and compatibility with automated synthesizers, streamlining the production of complex molecules. Whether for academic exploration or industrial scale-up, H-Gly-2-Chlorotrityl Resin remains a fundamental tool in modern organic synthesis, facilitating the efficient construction of peptide-based therapeutics and probes with precision and reliability.