Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales108@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
H-Ala-2-Chlorotrityl Resin is a specialized solid-phase synthesis reagent widely utilized in peptide chemistry for the efficient assembly of peptides. This product consists of L-alanine covalently attached to a 2-chlorotrityl chloride resin support via a stable ester linkage. The molecular formula is typically represented as C₁₉H₂₀ClNO₃ (excluding the polymer backbone), though the exact composition depends on the loading capacity of the specific resin batch. While it does not possess a single unique CAS number applicable to all commercial variants due to varying loadings and polymer types, generic identifiers often reference the specific functionalized material within chemical databases.
The primary application of H-Ala-2-Chlorotrityl Resin lies in its role as a starting point for automated or manual solid-phase peptide synthesis (SPPS). It serves as an ideal support for synthesizing C-terminal carboxylic acid peptides without requiring harsh acidic cleavage conditions that might damage acid-sensitive side chains. The 2-chlorotrityl linker allows for mild cleavage using weak acids like trifluoroacetic acid (TFA) mixed with scavengers, preserving the integrity of complex molecules such as those containing disulfide bonds or sensitive protecting groups. This makes it particularly valuable in pharmaceutical research, drug discovery, and academic laboratories where high purity and yield are critical.
Furthermore, this resin facilitates the rapid generation of peptide libraries, enabling high-throughput screening for biological activity. Its compatibility with standard Fmoc-based SPPS protocols ensures seamless integration into existing synthetic workflows. Researchers appreciate its robustness and ease of handling, which minimize degradation during the coupling cycles. By providing a reliable anchor for alanine residues, it supports the construction of diverse peptide sequences ranging from short oligomers to larger therapeutic candidates. As the demand for novel peptide-based therapeutics grows, H-Ala-2-Chlorotrityl Resin remains an essential tool for chemists aiming to accelerate development timelines while maintaining rigorous quality standards in medicinal chemistry projects worldwide.