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CAS NO:
68858-20-8
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Basic Info
CAS Number
68858-20-8
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales11@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Val-OH, chemically known as N-(9-Fluorenylmethoxycarbonyl)-L-valine, is a critical protected amino acid derivative widely utilized in solid-phase peptide synthesis (SPPS). With the molecular formula C18H17NO4 and a CAS number of 15326-03-9, this compound serves as an essential building block for constructing complex peptide sequences. The molecule features a valine residue, a non-polar, aliphatic amino acid, coupled with a fluorenylmethyloxycarbonyl (Fmoc) protecting group on its alpha-amino functionality. This specific protection strategy allows for orthogonal deprotection under mild basic conditions, typically using piperidine, without affecting other acid-labile side-chain protecting groups or the final peptide structure.
The primary application of Fmoc-Val-OH lies in the automated synthesis of peptides within pharmaceutical research and development. It enables the efficient assembly of therapeutic proteins, enzyme inhibitors, and diagnostic markers where valine plays a structural or functional role. Due to the steric bulk of the valine side chain, its incorporation requires careful optimization of coupling conditions to ensure high purity and yield, making it a standard reagent in optimizing synthetic protocols. Furthermore, this intermediate is frequently employed in the production of cyclic peptides and peptidomimetics, which are gaining traction for their enhanced metabolic stability compared to natural peptides.
In laboratory settings, Fmoc-Val-OH is supplied as a white crystalline powder with high purity grades suitable for both academic research and industrial manufacturing. Its solubility characteristics allow it to dissolve readily in common organic solvents such as dimethylformamide (DMF), dichloromethane, and dimethyl sulfoxide (DMSO), facilitating seamless integration into various SPPS workflows. Researchers rely on this compound to introduce hydrophobic interactions crucial for protein folding and stability during the design of novel bioactive molecules. As the demand for targeted therapies grows, the availability of high-quality Fmoc-protected amino acids like this one remains indispensable for advancing drug discovery pipelines and ensuring the precise synthesis of next-generation peptide-based therapeutics.
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