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Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales104@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Trp-Wang resin is a specialized solid-phase synthesis support widely utilized in peptide chemistry for the efficient construction of complex peptides containing tryptophan residues. This reagent consists of Wang resin, a polystyrene-based matrix functionalized with 4-hydroxymethylphenoxy groups, coupled to Fmoc-protected L-tryptophan. The molecular formula of the active moiety attached to the resin is typically represented as C23H26N2O5 relative to the free acid form before attachment, though the full resin structure includes the polymer backbone. While the specific CAS number varies depending on the substitution level and resin batch, the core Fmoc-Trp component is often associated with distinct identifiers used by major chemical suppliers like Sigma-Aldrich or Bachem.
The primary utility of Fmoc-Trp-Wang resin lies in its compatibility with the Fmoc/tBu strategy, which allows for orthogonal protection of amino acids during automated or manual solid-phase peptide synthesis (SPPS). The Fmoc group protects the amine functionality of tryptophan and can be easily removed using mild bases like piperidine without affecting side-chain protecting groups. Crucially, the Wang linker provides an acid-labile bond that facilitates the final cleavage of the completed peptide from the resin under mild acidic conditions, typically using trifluoroacetic acid (TFA). This cleavage mechanism yields the C-terminal carboxylic acid of the target peptide while preserving sensitive side chains.
Tryptophan is an essential aromatic amino acid found in numerous bioactive peptides and proteins, playing vital roles in fluorescence studies and biological signaling. Consequently, Fmoc-Trp-Wang resin is indispensable for pharmaceutical research, drug discovery, and academic laboratories synthesizing therapeutic candidates, diagnostic markers, and model peptides. Its high loading capacity and stability ensure consistent coupling efficiency and minimal racemization, making it a preferred choice for researchers aiming to produce high-purity tryptophan-containing sequences. By streamlining the synthesis process, this reagent significantly reduces reaction times and purification efforts, thereby accelerating the development of novel peptide-based therapeutics and advancing our understanding of protein structures and functions in modern biotechnology.
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