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Fmoc-Threoninol(tBu) DHP HM Resin
Price Range:
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 138g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales149@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Threoninol(tBu) DHP HM Resin is a specialized solid-phase synthesis reagent designed for the efficient production of peptide and peptidomimetic compounds. This resin features a controlled pore glass or polystyrene backbone functionalized with a 4-hydroxymethylphenoxy (DHP) linker, which provides high stability under acidic conditions while allowing mild cleavage protocols. The key structural component attached to the linker is Fmoc-protected threoninol bearing a tert-butyl (tBu) side-chain protection on the hydroxyl group. This specific configuration ensures that the chiral secondary alcohol remains protected during standard peptide assembly cycles using Fmoc/tBu chemistry, preventing unwanted side reactions such as O-acylation or racemization.
The primary application of this resin lies in the automated synthesis of complex therapeutic peptides, particularly those requiring a C-terminal amino alcohol motif. Threoninol serves as a valuable non-natural amino acid surrogate, often used to mimic peptide bonds or enhance metabolic stability in drug candidates. The tBu group protects the side-chain hydroxyl, ensuring selectivity during coupling steps, while the DHP linker facilitates the release of the final product using trifluoroacetic acid (TFA) without compromising sensitive residues. The "HM" designation typically refers to a high-molecular-weight or highly cross-linked matrix, offering superior swelling properties in organic solvents like dichloromethane and N,N-dimethylformamide, which enhances reaction kinetics and yield.
This reagent is indispensable for medicinal chemists developing novel bioactive molecules where precise stereochemistry and functional group integrity are paramount. By utilizing Fmoc-Threoninol(tBu) DHP HM Resin, researchers can streamline the synthesis of cyclic peptides, macrocycles, and modified protein sequences. Its robustness allows for multiple cleavage cycles and easy purification, making it a preferred choice in both academic research and industrial pharmaceutical manufacturing. The product supports the rapid generation of compound libraries for high-throughput screening, accelerating the discovery pipeline for new therapeutics targeting various diseases.
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