Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales102@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Thr-Wang Resin is a specialized solid-phase synthesis reagent widely utilized in the production of complex peptides and peptidomimetics. This product consists of L-threonine, protected by an N-terminal fluorenylmethyloxycarbonyl (Fmoc) group, covalently attached to a Wang resin support via a stable ester linkage. The chemical structure features a hydroxyethyl side chain on the threonine residue, which remains unprotected during standard Fmoc/tBu strategy protocols, allowing for selective modification or phosphorylation if required in later synthetic stages.
The molecular formula of the active moiety combined with the linker is typically represented as C24H30NO8Si when considering the silica-based support, though exact values vary slightly depending on the specific resin loading and cross-linking density. While the free amino acid has a distinct CAS number, the resin-bound form does not always carry a unique CAS identifier in commercial databases; however, it is universally recognized by its structural designation and manufacturer-specific catalog numbers. The primary application of Fmoc-Thr-Wang Resin lies in automated and manual solid-phase peptide synthesis (SPPS). Researchers employ this material to construct peptide chains starting from the C-terminus, where the Wang linker facilitates the final cleavage using mild acidic conditions, such as trifluoroacetic acid (TFA), yielding the desired peptide with a free carboxylic acid group.
This resin is particularly valuable for synthesizing bioactive peptides containing threonine residues, which are critical components in various biological signaling pathways, including kinase substrates and glycosylation sites. Its compatibility with standard deprotection reagents ensures high purity and yield, minimizing side reactions. Furthermore, the robustness of the Wang linker allows for the synthesis of long or difficult sequences without premature cleavage. Consequently, Fmoc-Thr-Wang Resin serves as an essential building block in pharmaceutical research, academic laboratories, and industrial drug discovery pipelines, enabling the efficient generation of therapeutic candidates and diagnostic probes. Its reliability makes it a staple inventory item for chemists focused on peptide engineering and structural biology studies.