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Fmoc-Lys(Boc)-Wang resin
Price Range:
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales94@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Lys(Boc)-Wang resin is a specialized solid-phase synthesis support widely utilized in the field of peptide chemistry for the efficient construction of complex polypeptides. This reagent consists of L-lysine, protected by an Fmoc (9-fluorenylmethyloxycarbonyl) group on the alpha-amino functionality and a Boc (tert-butoxycarbonyl) group on the epsilon-amino side chain, covalently attached to a Wang resin matrix via a linker. The Wang linker provides a stable anchor that allows for the final cleavage of the synthesized peptide under mild acidic conditions, typically using trifluoroacetic acid (TFA), yielding the free C-terminal carboxylic acid without requiring additional deprotection steps for the linker itself.
The molecular formula of the active component, Fmoc-Lys(Boc), is C27H36N2O6, though the full resin product includes the polymer backbone, usually polystyrene-based, which varies the overall empirical formula depending on the substitution level. While the specific CAS number applies strictly to the soluble amino acid derivative (often cited around 148650-08-6 for the Fmoc-Lys(Boc) moiety), commercial resin products are identified by manufacturer-specific catalog numbers rather than a single universal CAS. This dual protection strategy is critical; the Fmoc group ensures orthogonality during standard Fmoc/tBu SPPS protocols, allowing base-mediated removal, while the Boc group remains intact until the final global deprotection step.
This material is indispensable for synthesizing peptides containing lysine residues where side-chain protection is mandatory to prevent branching or cyclization errors during elongation. It finds extensive application in pharmaceutical research, particularly in the development of therapeutic peptides, vaccine candidates, and bioactive compounds requiring precise sequence control. Researchers utilize Fmoc-Lys(Boc)-Wang resin to ensure high purity and yield, minimizing racemization risks associated with activated intermediates. Its compatibility with automated synthesizers makes it a staple in both academic laboratories and industrial manufacturing settings. By offering a reliable platform for solid-phase assembly, this resin significantly accelerates the discovery and optimization of novel peptide-based drugs, contributing substantially to advancements in medicinal chemistry and biological science.
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