Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales91@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Ile-Wang resin is a specialized solid-phase synthesis reagent widely utilized in the pharmaceutical and biotechnology sectors for the efficient production of complex peptides. This material consists of L-isoleucine, protected by a fluorenylmethyloxycarbonyl (Fmoc) group on its alpha-amino functionality, covalently attached to a Wang resin support via an acid-labile linker. The molecular formula for the active Fmoc-Ile moiety is C19H21NO3, while the complete resin composition varies slightly depending on the specific cross-linking density and loading capacity of the polystyrene backbone, typically ranging from 0.5 to 1.2 mmol/g. A unique CAS number is generally not assigned to the entire resin matrix as it is a composite material; however, the individual chemical components possess distinct identifiers, with Fmoc-L-isoleucine carrying CAS No. 14673-86-8.
The primary application of Fmoc-Ile-Wang resin lies in automated peptide synthesis protocols. It serves as the foundational building block for constructing peptides where isoleucine is required at the N-terminus or internal positions. The Fmoc protecting group offers significant advantages over the traditional Boc strategy, allowing for orthogonal deprotection using mild bases like piperidine without affecting side-chain protections. Crucially, the Wang linker facilitates the final cleavage of the synthesized peptide under acidic conditions, such as treatment with trifluoroacetic acid (TFA), yielding the peptide with a free C-terminal carboxylic acid group. This makes the product indispensable for synthesizing therapeutic peptides, vaccine candidates, and diagnostic markers that require precise C-terminal structures. Its high stability during repetitive coupling cycles ensures excellent yields and purity, minimizing the need for extensive purification steps. Researchers favor this resin for its reliability in generating long-chain sequences and its compatibility with various standard solid-phase synthesis instruments. Consequently, Fmoc-Ile-Wang resin remains a critical component in modern medicinal chemistry laboratories dedicated to advancing drug discovery and protein engineering through precise, scalable peptide assembly.