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Fmoc-Glu(OtBu)-Wang resin
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales87@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Glu(OtBu)-Wang resin is a widely utilized solid-phase support in modern peptide synthesis, specifically designed for the efficient construction of glutamic acid-containing peptides. This reagent combines the stability of Wang resin with the orthogonal protection strategies required for Fmoc-based chemistry. The molecular formula for the active monomeric unit attached to the resin is typically represented as C25H31NO8Si (accounting for the linker and protecting group), though the exact mass varies slightly depending on the specific cross-linking density of the polystyrene backbone. While the resin itself does not possess a single unique CAS number due to its polymeric nature, the free amino acid component, Fmoc-Glu(OtBu), corresponds to CAS 109476-86-8, which serves as the precursor for loading onto the Wang support.
The primary utility of this product lies in its role as a key building block for Solid Phase Peptide Synthesis (SPPS). The Fmoc (9-fluorenylmethoxycarbonyl) group protects the alpha-amino functionality, allowing for selective deprotection under mild basic conditions using piperidine without affecting the side chain. Crucially, the glutamic acid side chain carboxyl group is protected by a tert-butyl (OtBu) ether. This group provides robust acid stability during the synthesis cycle but can be cleaved simultaneously with the final peptide from the resin using strong acids like trifluoroacetic acid (TFA). The Wang linker facilitates the formation of a C-terminal carboxylic acid upon cleavage, making this resin ideal for synthesizing native peptides where the C-terminus remains an acid rather than an amide.
Researchers frequently employ Fmoc-Glu(OtBu)-Wang resin to synthesize complex therapeutic peptides, including those containing phosphoserine or phosphorylated analogs, as well as various bioactive compounds requiring precise stereochemical control. Its compatibility with automated peptide synthesizers ensures high reproducibility and yield. By preventing premature side-chain reactions and ensuring clean cleavage profiles, this resin minimizes purification challenges associated with deletion sequences or incomplete couplings. Consequently, it remains a standard reagent in pharmaceutical research, academic laboratories, and industrial drug discovery pipelines aiming to produce high-purity glutamic acid-rich sequences for biological evaluation and clinical applications.
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