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Amino Acids and Derivatives
CAS NO:
71989-18-9
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Basic Info
CAS Number
71989-18-9
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales9@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Glu(OtBu)-OH, chemically known as N-[(9H-fluoren-9-yl)methoxycarbonyl]-L-glutamic acid 4-t-butyl ester, is a critical protected amino acid building block widely utilized in modern peptide synthesis. With the CAS number 136702-85-7, this compound features a molecular formula of C24H27NO7 and a precise molecular weight of 441.47 g/mol. The structure comprises an L-glutamic acid backbone where the alpha-amino group is protected by a fluorenylmethyloxycarbonyl (Fmoc) group, while the side-chain carboxylic acid is safeguarded by a tert-butyl ester. This dual protection strategy is essential for solid-phase peptide synthesis (SPPS), allowing for orthogonal deprotection sequences that ensure high purity and yield.
The Fmoc group is base-labile, typically removed using piperidine or other secondary amines, making it ideal for automated synthesis protocols. Conversely, the tert-butyl ester on the glutamate side chain remains stable under basic conditions but can be cleaved under acidic environments, such as with trifluoroacetic acid (TFA), at the final stage of synthesis to reveal the free carboxyl group. This specific arrangement prevents unwanted side reactions during chain elongation, particularly avoiding aspartimide formation or racemization, which are common pitfalls in synthesizing complex peptides containing glutamic acid residues.
Primarily employed in pharmaceutical research and biotechnology, Fmoc-Glu(OtBu)-OH serves as a fundamental reagent for constructing therapeutic peptides, including hormone analogs, enzyme inhibitors, and vaccine candidates. Its high chemical stability and solubility in common organic solvents like dichloromethane and DMF facilitate efficient coupling reactions with various activated amino acids. Researchers rely on this reagent to synthesize linear and cyclic peptides with precise structural integrity. Furthermore, its availability in high purity grades ensures reproducibility in both academic laboratories and industrial manufacturing settings. As the demand for peptide-based drugs grows, the role of protected amino acids like Fmoc-Glu(OtBu)-OH remains indispensable in advancing drug discovery and development pipelines globally.
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