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Fmoc-D-Ile-Wang resin
Price Range:
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales92@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-D-Ile-Wang resin is a specialized solid-phase synthesis support widely utilized in the field of peptide chemistry for the efficient construction of complex polypeptides. This reagent consists of L-isoleucine (specifically the D-enantiomer) covalently attached to a Wang resin linker via a stable amide bond, with its N-terminus protected by a 9-fluorenylmethoxycarbonyl (Fmoc) group. The chemical formula for the active residue portion is typically represented as C18H26NO4 (excluding the polymer backbone), though the full molecular weight varies depending on the resin loading capacity, which generally ranges from 0.5 to 1.0 mmol/g. While specific CAS numbers are often assigned to the free amino acid or specific derivatives rather than the loaded resin itself due to batch variability, the core component corresponds to the Fmoc-protected D-isomer of isoleucine.
The primary application of Fmoc-D-Ile-Wang resin lies in the automated and manual synthesis of peptides containing D-amino acids. Incorporating D-isoleucine is crucial for enhancing metabolic stability, improving protease resistance, and modulating the biological activity of therapeutic peptides, particularly in the development of antimicrobial agents and hormone analogs. The Wang linker offers significant advantages during the final cleavage step; upon treatment with strong acids like trifluoroacetic acid (TFA), it releases the completed peptide as a free carboxylic acid without requiring additional protecting groups on the C-terminus. Furthermore, the Fmoc protection strategy allows for orthogonal deprotection using mild bases such as piperidine, preserving side-chain functionalities throughout the synthesis cycle. This product is indispensable for medicinal chemists and researchers aiming to produce high-purity, enantiomerically pure peptides for drug discovery, structural biology studies, and diagnostic applications. Its compatibility with standard Fmoc/tBu protocols ensures streamlined workflows, making it a staple material in modern peptide laboratories focused on creating novel bioactive molecules with tailored stereochemical properties.
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