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Fmoc-Cys(Acm)-Wang resin
Price Range:
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales84@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Cys(Acm)-Wang resin is a specialized solid-phase synthesis support widely utilized in the field of peptide chemistry and pharmaceutical research. This reagent combines the stability of Wang resin with the orthogonal protection strategy provided by the Fmoc (9-fluorenylmethoxycarbonyl) group on the amino terminus and the Acm (acetamidomethyl) protecting group on the cysteine side chain thiol. The molecular formula for the active functional moiety attached to the resin matrix is typically represented as C27H28ClNO5Si, though the exact composition varies slightly depending on the specific cross-linking density and polymer bead type, often polystyrene-based. While a unique CAS number is not always assigned to the loaded resin itself due to its heterogeneous nature, the free acid precursor Fmoc-Cys(Acm)-OH carries the CAS identifier 134036-88-3.
The primary application of this product lies in the automated or manual synthesis of complex peptides containing cysteine residues. The Fmoc group allows for deprotection using mild bases like piperidine, facilitating stepwise chain elongation under standard conditions. Crucially, the Acm group offers robust protection against alkylation and oxidation during synthesis but remains stable to acidic cleavage conditions used to release the peptide from the resin. This orthogonality enables chemists to selectively remove the Acm group later using mild oxidizing agents such as iodine, allowing for precise disulfide bond formation without damaging other sensitive side chains. Consequently, Fmoc-Cys(Acm)-Wang resin is indispensable for producing therapeutic peptides, enzyme inhibitors, and diagnostic markers where correct disulfide connectivity is vital for biological activity. Its compatibility with various solvents and scalability make it a staple in both academic laboratories and industrial biopharmaceutical manufacturing facilities seeking high-purity, structurally defined peptide sequences. Researchers rely on this material to minimize side reactions and maximize yield when constructing multi-disulfide proteins that mimic natural physiological structures.
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