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Fmoc-Asp(OtBu)-Wang resin
Price Range:
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,
Australasia,Asia,Middle East,Africa
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Hangzhou Go Top Peptide Biotech Co.,Ltd.
2
Years
Basic Info
CAS Number
/
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Samples Provided
YES
Sample Policy
1-10mg for free
Packaging & Delivery
Packaging Specification
500mg,1g, 10g,50g 100g per package with icebag
Minimum Order Quantity
10mg
Delivery Cycle
In stock or 2-3 weeks
Product Description
Hangzhou Go Top Peptide Biotech Co., Ltd. is a national high-tech enterprise specializing in the research and development and production of peptides and related derivatives. It provides peptide-related custom synthesis and technology for domestic and foreign medical research and development, biotechnology, universities and scientific research institutions service. For consultation or ordering, please contact:86-571-88211951, 86-13588827304 (Cindy Mei), sales83@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Fmoc-Asp(OtBu)-Wang resin is a specialized solid-phase support widely utilized in modern peptide synthesis for the efficient assembly of complex polypeptides. Chemically, this reagent consists of a controlled-pore glass or polystyrene matrix functionalized with a Wang linker, which has been coupled to F-protected aspartic acid bearing a tert-butyl side-chain protecting group. The molecular formula for the active moiety attached to the resin is typically represented by the combination of the linker and the amino acid derivative, though exact values vary slightly based on the specific resin loading capacity, often ranging from 0.5 to 1.2 mmol/g. While the precise CAS number is not always assigned to the resin-bound form itself due to its heterogeneous nature, the precursor Fmoc-Asp(OtBu) generally carries the CAS identifier 143786-39-4.
The primary utility of this product lies in its compatibility with standard Fmoc/t-Bu orthogonal protection strategies. The Fmoc group on the alpha-amino position is removed under mild basic conditions using piperidine, allowing for stepwise chain elongation without affecting the acid-labile tert-butyl ester on the side chain. Simultaneously, the Wang linker ensures that the growing peptide remains anchored to the solid support throughout the synthesis cycle. Upon completion of the assembly, the final peptide can be cleaved from the resin using trifluoroacetic acid (TFA). This cleavage process simultaneously removes the t-butyl side-chain protecting groups and releases the peptide with a free C-terminal carboxylic acid, making it ideal for synthesizing peptides requiring unmodified carboxyl termini.
This resin is indispensable in pharmaceutical research, particularly for producing therapeutic peptides, vaccine candidates, and protein fragments where high purity and stereochemical integrity are paramount. Its robustness allows for automated synthesis on various platforms, ensuring reproducibility and scalability. Researchers favor Fmoc-Asp(OtBu)-Wang resin for its ability to minimize racemization during coupling steps and its efficiency in preventing aggregation issues common in difficult sequences. Consequently, it serves as a foundational building block in the rapid development of novel bioactive molecules across medicinal chemistry and biotechnology sectors.
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