Category:
Prophylactic Biological Products
CAS NO:
745-65-3
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Basic Info
CAS Number
745-65-3
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
分子式：
C20H34O5
分子量：
354.49
M.F:C5H12N2O2.C4H7NO4
L-ornithine-L-aspartate is useful in the treatment of high ammonia levels or when a patient’s liver function is extremely poor. L-O-L-A is very effective for end-stage cirrhotic patients.
AI Product Description
*The following content is generated by AI and is for reference only.
Alprostadil, chemically known as prostaglandin E1 (PGE1), is a synthetic form of a naturally occurring hormone-like substance found in the body. Its molecular formula is C20H34O5, and it carries the CAS registry number 713-67-9. This potent vasodilator plays a critical role in maintaining the patency of the ductus arteriosus in fetal circulation before birth. Following closure of this vessel after delivery, Alprostadil is utilized therapeutically to reopen or keep open the ductus arteriosus in neonates with specific congenital heart defects until surgical intervention becomes possible. Beyond pediatric cardiology, Alprostadil serves as a first-line treatment for erectile dysfunction (ED) in adult males. It works by relaxing smooth muscle tissue within the corpora cavernosa of the penis, thereby increasing blood flow and facilitating an erection independent of sexual stimulation. The drug is available in various formulations, including intracavernosal injection solutions, intraurethral suppositories, and topical gels, allowing for flexible administration based on patient needs and physician preference. Mechanistically, Alprostadil binds to specific receptors on vascular smooth muscle cells, activating adenylate cyclase which increases cyclic AMP levels, leading to muscle relaxation and subsequent vasodilation. While highly effective, its use requires careful medical supervision due to potential side effects such as penile pain, prolonged erection (priapism), hypotension, and dizziness. In neonatal care, precise dosing via continuous infusion is essential to avoid complications like fever, apnea, or seizures. As a prescription-only medication globally, Alprostadil represents a vital bridge between diagnosis and definitive treatment for life-threatening cardiac conditions in infants and a significant quality-of-life improvement for men suffering from organic erectile dysfunction. Ongoing research continues to explore novel delivery systems to enhance efficacy while minimizing adverse reactions, ensuring this versatile prostaglandin remains a cornerstone in modern urological and cardiovascular therapies worldwide.
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