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(3aR,7aR)-4-(1,2-Benzisothiazol-3-yl)octahydrospiro[2H-isoindole-2,1-piperazinium] methanesulfonate

Category:

Intermediates&Fine Chemicals

CAS NO:

186204-37-5

Standard:

ChP,USP,BP,EP,JP,ChP,

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Basic Info

CAS Number

186204-37-5

Pharmacopoeia

ChP,USP,BP,EP,JP,ChP

Product Keywords

(3aR,7aR)-4-(1,2-Benzisothiazol-3-yl)octahydrospiro[2H-isoindole-2,1-piperazinium] methanesulfonate,,Intermediates

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Product Description

AI Product Description

*The following content is generated by AI and is for reference only.

(3aR,7aR)-4-(1,2-Benzisothiazol-3-yl)octahydrospiro[2H-isoindole-2,1-piperazinium] methanesulfonate is a sophisticated chiral organic salt designed primarily for advanced pharmaceutical research and development. This compound features a complex spirocyclic architecture, combining an octahydrospiro[2H-isoindole-2,1-piperazine] core with a 1,2-benzisothiazole substituent at the C4 position. The specific stereochemistry denoted by (3aR,7aR) ensures a precise three-dimensional conformation, which is critical for high-affinity interactions with biological targets. As a methanesulfonate salt, the molecule exhibits enhanced water solubility and stability compared to its free base form, facilitating its use in aqueous-based assay systems and formulation studies. Currently, this substance does not possess a widely recognized commercial CAS number available in public databases, suggesting it may be a specialized intermediate synthesized for proprietary drug discovery programs or a unique research chemical not yet approved for clinical application. Its primary utility lies in medicinal chemistry, where it serves as a scaffold for structure-activity relationship (SAR) investigations. Researchers utilize such structurally rigidified molecules to probe receptor binding sites, particularly within the central nervous system or cardiovascular pathways, where stereoselectivity plays a pivotal role in therapeutic efficacy and safety profiles. The benzisothiazole moiety often contributes to metabolic stability and lipophilicity, while the spiro-piperazine framework offers a versatile platform for further derivatization. Due to its complexity and specific chirality, this compound is strictly intended for laboratory-scale synthesis, pharmacological screening, and academic inquiry rather than direct consumer use or over-the-counter applications. Handling requires adherence to strict laboratory safety protocols, including the use of appropriate personal protective equipment, given that many novel heterocyclic salts can exhibit unknown toxicological properties until fully characterized. It represents a niche but valuable tool in the quest for next-generation therapeutics, offering insights into how subtle stereochemical variations influence drug-receptor dynamics. Scientists continue to explore its potential as a lead compound for treating neurological disorders or other conditions requiring highly selective modulation of specific protein targets.