Besides the above products mentioned, there are still 7 anti-PD-(L)1 antibodies in Phase III clinical trials, and lung cancer is still one of the important indications the most companies lay out.

Among the products in Phase III clinical trials:
The blockbuster imported product atezolizumab is expected to be applied for marketing in China in 2019, which has been approved as a first-line therapy for non-squamous NSCLC in the U.S., being an indication expansion of great significance.
Furthermore, several imported products that enter China are noteworthy.
1. Novartis’ anti-PD-1 antibody PDR001 has been started Phase II clinical trial in China;
2. The cemiplimab co-developed by Regeneron/Sanofi has just started IND in China;
3. The IND application for the anti-PD-L1/TGF-β M7824 developed by Merck KGaA has been approved.
Attached table: Development Progress of Main Anti-PD-(L)1 antibodies in China
Pharmaceutical product | Target | Company | Progress in China | Imported / Chinese-produced | Marketed / late-stage clinical trial indication |
Nivolumab | PD-1 | BMS | Marketed | Imported | NSCLC |
Pembrolizumab | PD-1 | MSD | Marketed | Imported | Melanoma |
Toripalimab | PD-1 | Junshi Biosciences | Marketed | Chinese-produced | Melanoma |
Sintilimab | PD-1 | Innovent | Marketed | Chinese-produced | HL |
Camrelizumab | PD-1 | Hengrui Medicine | Applied for production | Chinese-produced | HL |
Tislelizumab | PD-1 | BeiGene | Applied for production | Chinese-produced | HL |
Durvalumab | PD-L1 | AstraZeneca | Applied for production | Imported | Stage III NSCLC |
Avelumab | PD-L1 | Pfizer | Phase III clinical trial | Imported | NSCLC |
KN035 | PD-L1 | Alphamab / 3D Medicines <...Read More
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