Ihe vertical counter-pressure rapid cooling sterilizer uses saturated steam as the sterilization medium, discharges the air in the cavity through gravity displacement, and uses saturated steam to kill all microorganisms under high pressure. The unique top-pressure water cooling system can achieve rapid cooling after sterilization. The sterilizer is suitable for the sterilization of items such as liquid loads, media, tissue culture and waste whichrequire high sterilization requirements.