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Other Specialized Reagents

Trifluoromethyl Sulfinyl Chloride

Category:

Other Specialized Reagents

CAS NO:

20621-29-8

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

20621-29-8

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

Trifluoromethyl sulfinyl chloride, chemically designated as CF₃SOCl, is a highly reactive and versatile organofluorine reagent widely utilized in synthetic organic chemistry. Its molecular formula is C F₃ Cl O S, and it is identified by the CAS Registry Number 356-17-8. This colorless to pale yellow liquid possesses a pungent odor and serves as a critical building block for introducing trifluoromethylthio (–SCF₃) or trifluoromethanesulfonyl (–SO₂CF₃) functionalities into complex molecular architectures. Due to the strong electron-withdrawing nature of the trifluoromethyl group combined with the electrophilic sulfur center, this compound exhibits exceptional reactivity toward nucleophiles, making it indispensable for the preparation of various fluorinated sulfones, sulfoxides, and thioesters. In pharmaceutical research and agrochemical development, Trifluoromethyl sulfinyl chloride is frequently employed to synthesize bioactive molecules where the presence of fluorine atoms significantly enhances metabolic stability, lipophilicity, and binding affinity. The reagent facilitates the efficient conversion of alcohols, amines, and thiols into their corresponding trifluoromethylsulfonyl derivatives under mild conditions. Furthermore, it acts as a key intermediate in the production of advanced materials, including high-performance polymers and liquid crystals, where specific electronic properties are required. Handling this substance requires strict adherence to safety protocols due to its corrosive nature and potential to release toxic hydrogen chloride gas upon contact with moisture. It must be stored in sealed containers under anhydrous conditions, typically at low temperatures, to prevent decomposition. As the demand for fluorinated compounds grows across diverse industries ranging from medicine to electronics, Trifluoromethyl sulfinyl chloride remains a cornerstone reagent for enabling novel chemical transformations and advancing the frontiers of functional material science.