*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>t-Boc Amine PEG Carboxyl is a protected polyethylene glycol linker featuring a tert-butyloxycarbonyl group on the amine terminus and a free carboxyl group. This bifunctional reagent facilitates site-specific conjugation in peptide synthesis via <strong>NHS ester coupling</strong>. The standard molecular formula is C<sub>n</sub>H<sub>2n+4</sub>O<sub>n+1</sub>(C<sub>5</sub>H<sub>9</sub>O<sub>2</sub>)N, with CAS numbers varying by PEG chain length (e.g., 85067-59-2 for PEG4).</p>
<h3>Application</h3>
<ul>
<li><strong>Peptide Drug Synthesis</strong>: Used to introduce hydrophilic PEG spacers into therapeutic peptides.</li>
<li><strong>Antibody-Drug Conjugates (ADCs)</strong>: Serves as a linker component for attaching cytotoxic payloads.</li>
<li><strong>Protein Bioconjugation</strong>: Enables modification of lysine residues while protecting the amine from side reactions.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C under inert atmosphere to prevent hydrolysis of the Boc or carboxyl groups. Handle in a fume hood due to potential irritant properties; avoid contact with skin and eyes during manufacturing processes.</p>