Side Chain of Tebipenem pivoxil,3-Azetidinethiol, 1-(4,5-dihydro-2-thiazolyl)-, monohydrochloride
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<h3>Overview</h3>
<p>Tebipenem pivoxil is a prodrug of the broad-spectrum carbapenem antibiotic tebibenem, designed for oral administration. The side chain features a pivaloyloxymethyl ester group attached to the carboxyl moiety, enhancing lipophilicity and intestinal absorption. <strong>Molecular Formula</strong>: C21H30N4O6S; <strong>CAS No.</strong>: 158897-97-9.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical Manufacturing</strong>: Synthesis of oral antibiotics for community-acquired pneumonia and urinary tract infections.</li>
<li><strong>R&D Laboratories</strong>: Reference standard for stability testing and bioequivalence studies.</li>
<li><strong>API Production</strong>: Intermediate in large-scale formulation of pediatric antibacterial agents.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly avoid use in patients with severe renal impairment or known hypersensitivity to beta-lactams. Store under inert atmosphere at -20°C to prevent hydrolysis of the ester side chain. Handle with appropriate PPE due to potential sensitization risks.</p>