*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Sacubitril-d4 is a <strong>deuterated isotopic standard</strong> of the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril. Synthesized via selective deuterium exchange, it features the molecular formula C<sub>27</sub>H<sub>19</sub>D<sub>4</sub>F<sub>3</sub>N<sub>2</sub>O<sub>6</sub> and CAS No. 1508186-57-3.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical R&D:</strong> Serves as an internal standard for LC-MS/MS quantification in pharmacokinetic studies.</li>
<li><strong>Clinical Trials:</strong> Enables precise metabolite profiling and stability testing of ARNI formulations.</li>
<li><strong>Quality Control:</strong> Validates analytical methods for impurity detection in bulk drug substances.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at -20°C to prevent isotopic dilution. Handle with appropriate PPE; avoid direct skin contact. Strictly for research use only, not for human therapeutic administration.</p>