*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>(S)-4-Hydroxy Mephenytoin is a specific enantiomer of the major active metabolite of mephenytoin, serving as a critical reference standard in pharmacokinetic studies. Synthesized via chiral resolution or asymmetric catalysis, its molecular formula is C<sub>12</sub>H<sub>13</sub>N<sub>2</sub>O<sub>2</sub> and CAS number is <strong>6578-90-7</strong>.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmacogenomics:</strong> Used to phenotype CYP2C19 activity for personalized dosing strategies.</li>
<li><strong>Drug Development:</strong> Serves as an internal standard in LC-MS/MS assays for bioequivalence trials.</li>
<li><strong>Toxicology:</strong> Applied in forensic analysis to detect mephenytoin exposure and metabolism rates.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly store under inert atmosphere at -20°C to prevent racemization. Handle with appropriate PPE due to potential irritancy; avoid environmental release during synthesis or analysis.</p>