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Other Specialized Reagents

(S)-(+)-2-Phenylglycinol

Category:

Other Specialized Reagents

CAS NO:

20989-17-7

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

20989-17-7

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

(S)-(+)-2-Phenylglycinol is a chiral building block of significant importance in the pharmaceutical and agrochemical industries. With the molecular formula C8H11NO and a CAS number of 6493-07-4, this optically active compound features a phenyl group attached to a glycinol backbone, creating a stereocenter that dictates its specific biological interactions. The molecule exists as a white to off-white crystalline solid or viscous liquid depending on purity and temperature, characterized by its high enantiomeric excess, which is crucial for asymmetric synthesis. The primary application of (S)-(+)-2-phenylglycinol lies in its role as a versatile intermediate for synthesizing complex heterocyclic compounds. It serves as a key precursor in the production of various bioactive molecules, including beta-lactam antibiotics such as cephalosporins and penicillins, where stereochemistry directly influences therapeutic efficacy and safety profiles. Furthermore, it is extensively utilized in the development of non-peptide protease inhibitors, angiotensin-converting enzyme (ACE) inhibitors, and other cardiovascular agents. In agrochemical research, this chiral amine contributes to the creation of selective herbicides and fungicides with enhanced environmental compatibility. From a synthetic chemistry perspective, the amino alcohol functionality allows for diverse transformations, including reductive amination, acylation, and cyclization reactions. Its ability to act as both a nucleophile and a ligand makes it invaluable in metal-catalyzed asymmetric reactions. Researchers often employ it to construct rigid scaffolds that mimic peptide structures while offering improved metabolic stability. Due to its commercial availability in high optical purity, it streamlines the drug discovery process, reducing the need for complex resolution steps. As the demand for enantiopure drugs grows globally, (S)-(+)-2-phenylglycinol remains an indispensable reagent for chemists aiming to develop next-generation therapeutics with precise stereocontrol. Its unique structural properties ensure continued relevance in organic synthesis laboratories worldwide, supporting advancements in medicinal chemistry and materials science.