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CAS NO:
126828-35-1
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Basic Info
CAS Number
126828-35-1
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
5g,10g,25g,50g,100g,500g
Minimum Order Quantity
5g
Delivery Cycle
In stock or 1-2weeks
Product Description
Hangzhou Go Top Peptide Biotech Co.,Ltd. - a reliable supplier of peptides synthesis.Our clients include * the pharma, cosmetic and biotech companies and research institutions worldwide. Welcome to contact us by email to sales51@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
Rink Amide Linker, often referred to in the context of Fmoc-protected solid-phase synthesis, is a critical reagent widely utilized in the automated synthesis of C-terminal amide peptides. Its chemical identity is typically defined as 4-[(4-methoxyphenyl)dimethylsilyl]methyl]-2-nitrobenzyl alcohol derivative, though commercially available as the Fmoc-protected variant with the specific structure 4-(4-methoxybenzyloxy)-2-nitrobenzyl alcohol linked to a polystyrene resin. The standard CAS number for the free acid form of Rink Amide Linker is 137690-58-1, while the Fmoc-protected version carries distinct identifiers depending on the manufacturer and resin loading. This linker serves as the bridge between the growing peptide chain and the solid support, specifically designed to facilitate the release of the final peptide product as a primary amide rather than a carboxylic acid.
The utility of Rink Amide Linker stems from its unique cleavage mechanism. During the final step of solid-phase peptide synthesis (SPPS), treatment with trifluoroacetic acid (TFA) or similar strong acidic cocktails cleaves the linker from the resin. Crucially, this process releases the peptide with a C-terminal -CONH2 group intact, which is essential for mimicking natural protein structures where many bioactive peptides terminate in an amide. Unlike linkers that yield free acids, Rink Amide ensures high fidelity for amide formation without requiring additional coupling steps post-synthesis. It is compatible with standard Fmoc/tBu protecting group strategies, making it a staple in pharmaceutical research, peptidomimetic development, and vaccine design. Researchers prefer this linker for synthesizing therapeutic candidates, diagnostic markers, and structural probes where the amide functionality is biologically imperative. Its robustness during synthesis cycles and clean cleavage profile minimize side reactions, ensuring high purity yields. Consequently, Rink Amide Linker remains a foundational tool in modern medicinal chemistry for generating complex peptide libraries and optimizing drug discovery pipelines efficiently.
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Copyright 2006-2025 (All Rights Reserved)
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