*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Rac-Ruxolitinib-d9 (major)</strong> is a deuterated isotopologue of the JAK1/2 inhibitor ruxolitinib, primarily utilized as an analytical reference standard. Its molecular formula is C<sub>22</sub>H<sub>25</sub>D<sub>9</sub>N<sub>7</sub>O, with CAS No. 260349-28-0. The core synthesis involves selective deuteration of the parent compound to ensure metabolic stability during pharmacokinetic studies.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical R&D:</strong> Serves as an internal standard for LC-MS/MS quantification in bioanalytical assays.</li>
<li><strong>Clinical Trials:</strong> Enables precise measurement of drug exposure and metabolite profiling in human plasma.</li>
<li><strong>Quality Control:</strong> Validates purity and identity of active pharmaceutical ingredients in manufacturing.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly for research use only; not intended for clinical administration. Store under inert atmosphere at -20°C to prevent hydrolysis. Personnel must utilize appropriate PPE including nitrile gloves and safety goggles during handling to avoid dermal absorption.</p>