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CAS NO:
128625-52-5
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Basic Info
CAS Number
128625-52-5
Pharmacopoeia
In-house Standards
Grade
Research grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
5g,10g,25g,50g,100g,500g
Minimum Order Quantity
5g
Delivery Cycle
In stock or 1-2weeks
Product Description
Hangzhou Go Top Peptide Biotech Co.,Ltd. - a reliable supplier of peptides synthesis.Our clients include * the pharma, cosmetic and biotech companies and research institutions worldwide. Welcome to contact us by email to sales24@gotopbio.com
AI Product Description
*The following content is generated by AI and is for reference only.
PyBOP, chemically known as (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, is a widely utilized coupling reagent in modern organic synthesis and peptide chemistry. Its molecular formula is C24H30F6N7O4P, and it is registered under the CAS number 76589-35-0. This reagent serves as a highly efficient alternative to traditional carbodiimide-based activators like DCC or EDC, offering superior performance in amide bond formation without the risk of racemization that often plagues other methods.
The primary application of PyBOP lies in solid-phase peptide synthesis (SPPS) and solution-phase peptide coupling reactions. It facilitates the rapid activation of carboxylic acids by converting them into highly reactive benzotriazole esters, which then readily react with amines to form stable amide bonds. A distinct advantage of PyBOP over its predecessor, HOBt-based reagents, is that it generates non-toxic byproducts, specifically tetramethylurea and benzotriazole, rather than hazardous urea derivatives. Furthermore, PyBOP exhibits excellent solubility in common polar aprotic solvents such as dimethylformamide (DMF) and dichloromethane (DCM), making it versatile for various synthetic protocols.
In pharmaceutical research, PyBOP is indispensable for constructing complex peptidomimetics, macrocycles, and drug candidates where stereochemical integrity is paramount. Its ability to drive reactions to completion quickly under mild conditions significantly reduces side reactions and improves overall yields. While PyBOP is generally considered safe when handled with standard laboratory precautions, it should be stored in a cool, dry place away from moisture to prevent premature decomposition. Despite the emergence of newer coupling agents, PyBOP remains a gold standard in laboratories worldwide due to its reliability, cost-effectiveness, and consistent performance in synthesizing high-purity peptides and bioactive molecules essential for drug discovery and biochemical analysis.
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Copyright 2006-2025 (All Rights Reserved)
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