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Other Specialized Reagents

Prednisolone Base

Category:

Other Specialized Reagents

CAS NO:

50-24-8

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

50-24-8

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Intermediates for plating and pharmaceutical materials

AI Product Description

*The following content is generated by AI and is for reference only.

Prednisolone Base is a potent synthetic glucocorticoid widely utilized in clinical and pharmaceutical settings for its robust anti-inflammatory, immunosuppressive, and antiallergic properties. Chemically identified by the CAS number 50-24-8, this compound possesses the molecular formula C₂₁H₂₈O₅ and a molecular weight of approximately 360.44 g/mol. Structurally, it serves as the active metabolite of prednisone, distinguishing itself by lacking the need for hepatic conversion to exert therapeutic effects, which makes it particularly valuable for patients with compromised liver function. The molecule features a characteristic steroid nucleus with specific hydroxyl and ketone groups that facilitate high-affinity binding to intracellular glucocorticoid receptors, thereby modulating gene expression to suppress inflammatory pathways. In medical practice, Prednisolone Base is a cornerstone treatment for a diverse array of conditions, including severe allergic reactions, asthma exacerbations, rheumatoid arthritis, systemic lupus erythematosus, and various dermatological disorders such as severe eczema and psoriasis. It is also employed in organ transplantation protocols to prevent graft rejection and in the management of certain hematologic malignancies like leukemia and lymphoma. Due to its high bioavailability when administered orally or topically, it offers rapid symptom relief while minimizing the risk of fluid retention compared to some other corticosteroids. However, long-term usage requires careful monitoring due to potential side effects, including hyperglycemia, osteoporosis, hypertension, and adrenal suppression. As a critical intermediate in drug manufacturing, Prednisolone Base is often processed into various salt forms, such as sodium phosphate or acetate, to enhance solubility and stability for injectable or ophthalmic formulations. Its versatility ensures its continued status as an essential component in global pharmacopeias, providing life-saving intervention for millions of patients suffering from chronic inflammatory and autoimmune diseases worldwide.