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CAS NO:
9000-55-9
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podophyllum resin,Podophylline 9000-55-9
Price Range:
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Main Sales Markets:
North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
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Xi'an Haoxuan Bio-Tech Co., Ltd.
7
Years
Basic Info
CAS Number
9000-55-9
Pharmacopoeia
ChP,USP,BP,EP
Grade
Pharmaceutical Grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
Double plastic bag inside 25Kg/Fiber Drum or 1kg aluminum foil vacuum bag packing for samples
Minimum Order Quantity
1kg
Delivery Cycle
3 days
Product Description
Main Function:
Can effectively inhibit the herpes virus, inhibit cell mitosis mid for viral sexually transmitted diseases, more than 98% of 0.5% podophyllotoxin tincture made of men and women for the treatment of venereal warts significant effect.
AI Product Description
*The following content is generated by AI and is for reference only.
Podophyllum resin, primarily known for its active constituent podophyllotoxin (often referred to as podophylline in commercial contexts), is a potent natural extract derived from the rhizomes and roots of *Podophyllum peltatum* and related species. While the specific CAS number 9000-55-9 typically identifies pure Podophyllotoxin rather than the crude resin mixture, this compound serves as a critical precursor in pharmaceutical synthesis. The molecular formula of podophyllotoxin is C22H22O8, with a molecular weight of approximately 414.4 g/mol. This lignan derivative exhibits significant biological activity, most notably as an antimitotic agent that inhibits cell division by disrupting microtubule assembly.
Historically, crude Podophyllum resin has been utilized in topical formulations for the treatment of external genital warts caused by human papillomavirus (HPV). Its mechanism involves the destruction of infected tissue through cytotoxic action, making it a standard therapy for condyloma acuminata when applied carefully under medical supervision. However, due to the narrow therapeutic index and potential systemic toxicity associated with oral or excessive dermal absorption, modern medicine often favors semi-synthetic derivatives like etoposide and teniposide. These derivatives are synthesized from podophyllotoxin and are widely employed as chemotherapeutic agents for treating various malignancies, including testicular cancer, lung cancer, and lymphomas. They function by stabilizing the DNA-topoisomerase II complex, thereby preventing DNA religation and inducing apoptosis in rapidly dividing tumor cells.
Despite its clinical value, Podophyllum resin requires strict regulatory handling. It is not suitable for self-medication due to risks of severe local irritation, systemic absorption leading to bone marrow suppression, and neurotoxicity. Furthermore, the supply chain relies on sustainable harvesting practices, as over-harvesting threatens wild populations of the source plants. In industrial applications, high-purity podophyllotoxin is essential for the efficient production of anticancer drugs, driving continuous research into plant cell culture techniques to ensure a stable and ethical supply. Overall, while the crude resin remains relevant for dermatological treatments, its true global impact lies in its role as the foundational scaffold for life-saving oncology medications.
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