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<h3>Overview</h3>
<p>Pimecrolimus is a non-steroidal calcineurin inhibitor synthesized via <strong>macrocyclization</strong>. It functions as an immunomodulator for topical dermatological use. Its chemical identity is defined by the molecular formula <strong>C41H59NO12</strong> and CAS number <strong>167088-49-5</strong>.</p>
<h3>Application</h3>
<ul>
<li><strong>Dermatology:</strong> First-line treatment for mild-to-moderate atopic dermatitis in adults and children.</li>
<li><strong>Clinical Research:</strong> Investigated for off-label management of vitiligo and lichen planus.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated in patients with compromised immune systems or active skin infections. Store under <strong>controlled room temperature</strong> (20°C–25°C) in original packaging to maintain stability. Avoid contact with eyes and mucous membranes during application.</p>