LY338979;N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMicAcid;PeMetrexedIMpurity(MixtureofDiastereoMers)(N-[4-[2-(2-AMino-4,5,6,7-teChemicalbooktrahydro-4,6-dioxo-1H-pyrrolo[2.3-d]-pyriMidi;Pemetrexed6-OxoDiacidImpurity;PemetrexedImpurity18;PemetrexedKetoimpurity;Pemetrexedimpurities7;Pemetrexed6-OxoDiacidImpurity(ketopemetrexed)
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Pemetrexed Impurity refers to <strong>process-related substances</strong> or <strong>degradants</strong> generated during the synthesis of the anticancer drug Pemetrexed. These impurities are critical for quality control, ensuring the final pharmaceutical product meets international purity standards. The molecular formula and CAS number vary depending on the specific isomer or byproduct structure.</p>
<h3>Application</h3>
<ul>
<li><strong>Quality Control:</strong> Used as reference standards in HPLC analysis to identify and quantify trace impurities in bulk drugs.</li>
<li><strong>R&D:</strong> Essential for method development and stability testing during drug formulation.</li>
<li><strong>Regulatory Compliance:</strong> Required for dossier submissions to agencies like FDA and EMA to demonstrate safety profiles.</li>
</ul>
<h3>Precautions</h3>
<p>Store strictly under <strong>inert atmosphere</strong> at controlled temperatures (2-8°C) to prevent degradation. Handle with appropriate <strong>PPE</strong> including gloves and masks due to potential cytotoxicity. Avoid direct contact and ensure proper ventilation in laboratory settings.</p>