*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Polyethylene glycol bis(2-thiol) is a bifunctional thiolated PEG reagent used for bioconjugation. The core process involves nucleophilic substitution to introduce reactive sulfhydryl groups. Molecular formula: <strong>C<sub>n</sub>H<sub>2n+4</sub>O<sub>n</sub>S<sub>2</sub></strong>. CAS No.: <strong>Not universally assigned</strong>.</p>
<h3>Application</h3>
<ul>
<li><strong>Drug Delivery:</strong> Conjugation of peptides and proteins to enhance pharmacokinetics.</li>
<li><strong>Material Science:</strong> Synthesis of hydrogels via thiol-ene click chemistry crosslinking.</li>
<li><strong>Diagnostics:</strong> Functionalization of nanoparticles for targeted imaging agents.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at 2-8°C to prevent oxidation. Wear appropriate PPE; avoid skin contact due to potential irritation. Not approved for direct clinical use without further formulation validation.</p>