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Other Specialized Reagents

Methyl 2-Bromoisonicotinate

Category:

Other Specialized Reagents

CAS NO:

26156-48-9

Standard:

BP,USP,

Price Range:

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Main Sales Markets:

North America,Western Europe,Eastern Europe

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Shanghai Sunwise Chemical Co., Ltd.

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Basic Info

CAS Number

26156-48-9

Pharmacopoeia

BP,USP

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Pharmaceutical Raw Materials and Intermediates

AI Product Description

*The following content is generated by AI and is for reference only.

Methyl 2-Bromoisonicotinate is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds. Chemically identified by the CAS number 5780-34-1, this compound features a pyridine ring substituted with a methyl ester group at the first position and a bromine atom at the second position. Its molecular formula is C7H6BrNO2, reflecting a precise arrangement that offers high reactivity for various nucleophilic substitution and cross-coupling reactions. The presence of the bromine substituent makes it an excellent electrophile, particularly suitable for palladium-catalyzed cross-coupling methodologies such as Suzuki-Miyaura, Heck, and Sonogashira reactions. These transformations are fundamental in constructing biologically active scaffolds found in modern drug discovery pipelines. In practical applications, Methyl 2-Bromoisonicotinate serves as a critical building block for synthesizing pyridine-based derivatives, which are structural motifs common in numerous therapeutic agents. It is frequently employed to develop antimalarial drugs, antiviral compounds, and potential anticancer agents where specific pyridine substitutions are required for optimal biological activity. Furthermore, its utility extends to the production of advanced materials and ligands used in catalysis and coordination chemistry. The compound is typically supplied as a stable crystalline solid or liquid depending on purity grades, requiring standard laboratory handling procedures due to its halogenated nature. Researchers value this reagent for its commercial availability and consistent quality, ensuring reproducible results in multi-step synthetic sequences. By facilitating the efficient introduction of diverse functional groups onto the pyridine core, it accelerates the development of novel chemical entities. Consequently, Methyl 2-Bromoisonicotinate remains an indispensable tool for chemists aiming to innovate in medicinal chemistry and material science, bridging the gap between simple starting materials and sophisticated bioactive molecules through robust and versatile synthetic strategies.