*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Methoxy PEG Succinimidyl Glutarate is a heterobifunctional PEG reagent used for bioconjugation. It features an N-hydroxysuccinimide (NHS) ester group reactive with primary amines and a methoxy-terminated polyethylene glycol chain. The compound typically exhibits a molecular formula of C<sub>x</sub>H<sub>y</sub>N<sub>z</sub>O<sub>w</sub> and carries CAS numbers dependent on specific PEG chain lengths.</p>
<h3>Application</h3>
<ul>
<li><strong>Antibody-Drug Conjugates (ADCs):</strong> Linking cytotoxic payloads to monoclonal antibodies via amine groups.</li>
<li><strong>Protein Modification:</strong> Extending serum half-life of therapeutic proteins through pegylation.</li>
<li><strong>Diagnostics:</strong> Immobilizing enzymes or antigens onto solid supports for immunoassays.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C under inert atmosphere to prevent hydrolysis. Handle in a fume hood as NHS esters are lachrymators and potential sensitizers. Not intended for direct clinical administration without further formulation and regulatory approval.</p>