*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Methoxy PEG Succinimidyl Carboxymethyl Ester is a heterobifunctional PEG reagent used for protein conjugation. It features an N-hydroxysuccinimide (NHS) ester group reacting with primary amines and a carboxymethyl moiety for further modification. The compound typically follows the formula <strong>C<sub>n</sub>H<sub>2n+1</sub>O<sub>m</sub>(CH<sub>2</sub>CH<sub>2</sub>O)<sub>k</sub>COOH</strong>. Specific CAS numbers vary by PEG chain length, commonly ranging from 87056-40-4 to higher homologs.</p>
<h3>Application</h3>
<ul>
<li><strong>Antibody-Drug Conjugates (ADCs):</strong> Linking cytotoxic payloads to monoclonal antibodies via amine residues.</li>
<li><strong>Peptide Synthesis:</strong> Introducing solubility tags or reactive handles into therapeutic peptides.</li>
<li><strong>Bioconjugation:</strong> Attaching fluorophores, enzymes, or affinity ligands to biomolecules for diagnostics.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C under inert atmosphere to prevent hydrolysis. Avoid skin contact as NHS esters are potential sensitizers. Not intended for direct clinical administration; requires purification before use in pharmaceutical formulations.</p>