*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Methoxy PEG Maleimide is a heterobifunctional reagent featuring a <strong>methoxy-terminated polyethylene glycol</strong> chain and a reactive maleimide group. This structure enables efficient conjugation with thiol-containing biomolecules via Michael addition under mild conditions.</p>
<h3>Application</h3>
<ul>
<li><strong>Antibody-Drug Conjugates (ADCs)</strong>: Site-specific attachment of cytotoxic payloads to monoclonal antibodies.</li>
<li><strong>Protein Modification</strong>: Labeling enzymes or therapeutic proteins for stability enhancement and pharmacokinetic optimization.</li>
<li><strong>Bioconjugate Synthesis</strong>: Fabrication of diagnostic probes and polymer-drug hybrids.</li>
</ul>
<h3>Precautions</h3>
<p>Store at <strong>-20°C</strong> in a dry, inert atmosphere to prevent hydrolysis. Handle in a fume hood using appropriate PPE; avoid skin contact as it may cause sensitization. Not approved for direct clinical use without formulation.</p>