*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Methotrexate gamma-Methyl Ester is a specialized prodrug derivative of methotrexate, synthesized via esterification to enhance lipophilicity and oral bioavailability. Its molecular formula is C<sub>21</sub>H<sub>24</sub>N<sub>8</sub>O<sub>5</sub>, with CAS No. 6307-07-9.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical R&D:</strong> Utilized as an intermediate for developing novel antifolate agents with improved pharmacokinetic profiles.</li>
<li><strong>Oncology Research:</strong> Investigated in preclinical studies to optimize drug delivery systems targeting rapidly dividing cells.</li>
<li><strong>Biochemical Assays:</strong> Serves as a substrate in enzyme inhibition studies involving dihydrofolate reductase.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly regulated as a research chemical; not approved for human clinical use. Store under inert atmosphere at -20°C to prevent hydrolysis. Handle with appropriate PPE due to potential cytotoxicity and reproductive hazards.</p>