*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Methotrexate-d3</strong> is a deuterated internal standard for quantitative analysis via LC-MS/MS. Synthesized via catalytic deuteration, it ensures accurate measurement of methotrexate in biological matrices. Molecular Formula: C20H14D3N5O5; CAS No.: 187969-63-3.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical R&D:</strong> Bioequivalence studies and PK/PD modeling.</li>
<li><strong>Clinical Diagnostics:</strong> Therapeutic drug monitoring (TDM) in oncology and rheumatology.</li>
<li><strong>Toxicology:</strong> Quantification in forensic screening and overdose cases.</li>
</ul>
<h3>Precautions</h3>
<p>Store at -20°C under inert atmosphere to prevent degradation. Handle with PPE due to potential cytotoxicity. Strictly controlled as a reference material for analytical calibration only.</p>