*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Maleimide PEG Carboxyl</strong> is a heterobifunctional polyethylene glycol derivative featuring a maleimide group for thiol conjugation and a carboxyl group for amine coupling. Synthesized via nucleophilic substitution, it typically follows the general formula HOOC-PEG-Maleimide with CAS numbers like 168472-50-8 depending on MW.</p>
<h3>Application</h3>
<ul>
<li>Antibody-Drug Conjugates (ADCs) for targeted cancer therapy delivery.</li>
<li>Protein bioconjugation to enhance stability and solubility of therapeutic peptides.</li>
<li>Diagnostic probe development for attaching fluorophores or biotin labels.</li>
<li>Nanoparticle surface functionalization in drug delivery systems.</li>
</ul>
<h3>Precautions</h3>
<ul>
<li>Store at -20°C under inert atmosphere to prevent hydrolysis.</li>
<li>Avoid contact with strong reducing agents which cleave maleimide rings.</li>
<li>Use appropriate PPE; strictly limit exposure during clinical manufacturing.</li>
</ul>